In Japan, supplements are commonly made by mixing ingredients that are considered beneficial for health and are sold separately from medicine. In particular, many supplements use a lot of natural ingredients and are free of additives or have obtained organic certification. Also, in Japan, it is common to consult with doctors or experts when taking supplements, and they are produced with consideration for safety. Many manufacturers are also large and reliable companies, and high-quality supplements are provided. Additionally, supplements in Japan are said to be effective even with small doses compared to those in Europe and America, and can be taken continuously on a daily basis.